Manton is building his new microblogging platform on top of Jekyll. That makes a ton of sense.
On top of Jekyll, I built a web interface for publishing and deleting posts, changing themes, and I added XML-RPC support so that you can use external blog editors like MarsEdit. Plus there's a native iPhone app for posting.
It's tough for me to imagine moving away from my funky little Pelican setup, but this really sounds great for a lot of people.